phil baran

Professor of Chemistry, The Scripps Research Institute. Chem. 2010, 132, 7119 – 7137. 3. Chem. A., deGruyter, J. N., Baran, P. S. Peters, B. K., Rodriguez, K. X., Reisberg, S. H., Beil, S. B., Hickey, D. P., Kawamata, Y., Collins, M., Starr, J., Chen, L., Udyavara, S., Klunder, K., Gorey, T. J., et al. B., Su, S., Rodriguez, R. A., Gianatassio, R., Fujiwara, Y., Sobel, A. L., Baran, P. S. Chen, K., Ishihara, Y., Galan, M. M., Baran, P. S. Newhouse, T., Lewis, C. A., Eastman, K. J., Baran, P. S. Schultz, A. W., Lewis, C. A., Luzung, M. R., Baran, P. S., Moore, B. S. Cipres, A., O'Malley, D. P., Li, K., Finlay, D., Baran, P. S., Vuori, K. Sella, E., Weinstain, R., Erez, R., Burns, N. Z., Baran, P. S., Shabat, D. Seiple, I. Soc., 2011, 133, 13922 – 13925. Burns, N.Z. He consults for numerous companies such as Bristol-Myers Squibb (since late 2005), Boehringer-Ingelheim, AstraZeneca, DuPont and TEVA, and is a scientific advisory board member for Eisai, Abide, and AsymChem. Articles Cited by Co-authors. The Skaggs Institute for Chemical Biology, Skaggs Graduate School of Chemical and Biological Sciences, NIH Postdoctoral Fellow with Dr. E. J. Corey, RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis, Electrosynthesis: Sustainability Is Not Enough, Enantiodivergent Formation of C-P Bonds: Synthesis of P-Chiral Phosphines and Methylphosphonate Oligonucleotides, Electrifying Synthesis: Recent Advances in the Methods, Materials, and Techniques for Organic Electrosynthesis, Total synthesis reveals atypical atropisomerism in a small-molecule natural product, tryptorubin A, Two-Phase Total Synthesis of Taxanes: Tactics and Strategies, A survival guide for the "Electro-curious", Hindered dialkyl ether synthesis with electrogenerated carbocations, Impact of stereo- and regiochemistry on energetic materials, Expanding reactivity in DNA-encoded library synthesis via reversible binding of DNA to an inert quaternary ammonium support, Cluster preface: electrochemical synthesis and catalysis, Modular, stereocontrolled Cβ-H/Cα-C activation of alkyl carboxylic acids, A radical approach to anionic chemistry: synthesis of ketones, alcohols, and amines, Electrochemically driven, Ni-catalyzed aryl amination: scope, mechanism, and applications, Alkyl sulfinates: radical precursors enabling drug discovery, Scalable and safe synthetic organic electroreduction inspired by Li-ion battery chemistry, Quaternary centers by nickel-catalyzed cross-coupling of tertiary carboxylic acids and (hetero)aryl zinc reagents, 11-step total synthesis of teleocidins B-1-6-4, Direct carbon isotope exchange through decarboxylative carboxylation, Concise total synthesis of herqulines B and C, Didehydro-cortistatin A inhibits HIV-1 by specifically binding to the unstructured basic region of Tat, A general amino acid synthesis enabled by innate radical cross-coupling, Unlocking P(V): Reagents for chiral phosphorothioate synthesis, Divergent synthesis of thapsigargin analogs, Building C(sp3)-rich complexity by combining cycloaddition and C-C cross-coupling reactions, Kinetically guided radical-based synthesis of C(sp(3))-C(sp(3)) linkages on DNA, Divergent synthesis of pyrone diterpenes via radical cross coupling, Natural product total synthesis: as exciting as ever and here to stay, Synthetic organic electrochemistry: calling all engineers, Modular radical cross-coupling with sulfones enables access to sp(3)-rich (fluoro)alkylated scaffolds, Scalable access to arylomycins via C-H functionalization logic, Chemical proteomics identifies SLC25A20 as a functional target of the ingenol class of actinic keratosis drugs, CITU: a peptide and decarboxylative coupling reagent, Synthetic organic electrochemical methods since 2000: on the verge of a renaissance, Electrochemically enabled, nickel-catalyzed amination, Development of the large-scale synthesis of tetrahydropyran glycine, a precursor to the HCV NS5A inhibitor BMS-986097, Decoding the Mechanism of Intramolecular Cu-Directed Hydroxylation of sp3 C-H Bonds, BMS-663068: Another quiet victory for chemistry, Residue-Specific Peptide Modification: A Chemist's Guide, Scalable, electrochemical oxidation of unactivated C-H bonds, Peptide macrocyclization inspired by non-ribosomal imine natural products, Alkyl-(hetero)aryl bond formation via decarboxylative cross-coupling: A systematic analysis, Strain-release heteroatom functionalization: Development, scope, and stereospecificity, Fe-catalyzed C-C bond construction from olefins via radicals, Nickel-catalyzed barton decarboxylation and giese reactions: a practical take on classic transforms, Radicals: reactive intermediates with translational potential, Redox-active esters in Fe-catalyzed C-C coupling, A practical approach for enantio- and diastereocontrol in the synthesis of 2,3-disubstituted succinic acid esters: synthesis of the pan-Notch inhibitor BMS-906024, Tagging the untaggable: a difluoroalkyl-sulfinate ketone-based reagent for direct C-H functionalization of bioactive heteroarenes, Nickel-catalyzed cross-coupling of redox-active esters with boronic acids, 11-step total synthesis of (-)-maoecrystal V, Short, enantioselective total synthesis of highly oxidized taxanes, 11-step total synthesis of pallambins C and D, Synthetic organic electrochemistry: an enabling and innately sustainable method, Drug discovery: Fighting evolution with chemical synthesis, A general alkyl-alkyl cross-coupling enabled by redox-active esters and alkylzinc reagents, Scalable and sustainable electrochemical allylic C-H oxidation, Nineteen-step total synthesis of (+)-phorbol, Practical Ni-catalyzed aryl-alkyl cross-coupling of secondary redox-active esters, Antroquinonol A: scalable synthesis and preclinical biology of a phase 2 drug candidate, C-H oxidation of ingenanes enables potent and selective protein kinase C isoform activation, Scalable C-H oxidation with copper: synthesis of polyoxypregnanes, Total synthesis of verruculogen and fumitremorgin a enabled by ligand-controlled C-H borylation, Organic chemistry: A cure for catalyst poisoning, Response to Comment on "Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence", Scalable total syntheses of (-)-hapalindole U and (+)-ambiguine H, Practical olefin hydroamination with nitroarenes, Discovery of clinical candidate BMS-906024: A potent pan-notch inhibitor for the treatment of leukemia and solid tumors, Academia-industry symbiosis in organic chemistry, Development of a concise synthesis of ouabagenin and hydroxylated corticosteroid analogues, Synthesis of biologically active piperidine metabolites of clopidogrel: determination of structure and analyte development, Quinone diazides for olefin functionalization, Mechanism, reactivity, and selectivity of nickel-catalyzed [4 + 4 + 2] cycloadditions of dienes and alkynes, Improving physical properties via C-H oxidation: chemical and enzymatic approaches, Axinellamines as broad-spectrum antibacterial agents: scalable synthesis and biology, Radical C-H functionalization of heteroarenes under electrochemical control, Asymmetric syntheses of sceptrin and massadine and evidence for biosynthetic enantiodivergence, One-pot enzymatic synthesis of merochlorin A and B, A unified approach to ent-atisane diterpenes and related alkaloids: synthesis of (-)-methyl atisenoate, (-)-isoatisine, and the hetidine skeleton, Simple sulfinate synthesis enables C-H trifluoromethylcyclopropanation, Palau'chlor: a practical and reactive chlorinating reagent, Development of a concise synthesis of (+)-ingenol, Total synthesis of dixiamycin B by electrochemical oxidation, A mild, ferrocene-catalyzed C-H imidation of (hetero)arenes, C-H methylation of heteroarenes inspired by radical SAM methyl transferase, Two-phase synthesis of (-)-taxuyunnanine D, Applications of C-H functionalization logic to cyclobutane synthesis, A simple litmus test for aldehyde oxidase metabolism of heteroarenes, A practical and catalytic reductive olefin coupling, Functionalized olefin cross-coupling to construct carbon-carbon bonds, Natural product synthesis in the age of scalability, Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement, Bioconjugation by native chemical tagging of C-H bonds, 14-step synthesis of (+)-ingenol from (+)-3-carene, Synthesis of ent-kaurane and beyerane diterpenoids by controlled fragmentations of overbred intermediates, Radical-based regioselective C-H functionalization of electron-deficient heteroarenes: scope, tunability, and predictability, C-H functionalization logic enables synthesis of (+)-hongoquercin A and related compounds, Total synthesis of taxane terpenes: cyclase phase, Preparation and purification of zinc sulfinate reagents for drug discovery, Convergent synthesis and structural confirmation of phellodonin and sarcodonin epsilon, Enhanced reactivity in dioxirane C-H oxidations via strain release: a computational and experimental study, Regioselective bromination of fused heterocyclic N-oxides, Strategic redox relay enables a scalable synthesis of ouabagenin, a bioactive cardenolide, Direct synthesis of fluorinated heteroarylether bioisosteres, "Donor-two-acceptor" dye design: a distinct gateway to NIR fluorescence, Practical and innate carbon-hydrogen functionalization of heterocycles, Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities, Guided desaturation of unactivated aliphatics, An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription, Why a proximity-induced Diels-Alder reaction is so fast, Innate and guided C-H functionalization logic, Scalable, divergent synthesis of meroterpenoids via "borono-sclareolide", Palau'amine and related oroidin alkaloids dibromophakellin and dibromophakellstatin inhibit the human 20s proteasome, Intermolecular Ritter-type C-H amination of unactivated sp3 carbons, Configurational analysis of tetracyclic dimeric pyrrole-imidazole alkaloids using a floating chirality approach, A new reagent for direct difluoromethylation, An approach to mimicking the sesquiterpene cyclase phase by nickel-promoted diene/alkyne cooligomerization, Scalable enantioselective total synthesis of taxanes, Scalable, enantioselective synthesis of germacrenes and related sesquiterpenes inspired by terpene cyclase phase logic, Sequential C(sp3)-H arylation and olefination: total synthesis of the proposed structure of pipercyclobutanamide A, Strained cyclophane natural products: Macrocyclization at its limits, Total synthesis and structural revision of the piperarborenines via sequential cyclobutane C-H arylation, Practical radical cyclizations with arylboronic acids and trifluoroborates, Enantioselective total syntheses of (-)-palau'amine, (-)-axinellamines, and (-)-massadines, Scalable, stereocontrolled total syntheses of (±)-axinellamines A and B, Innate C-H trifluoromethylation of heterocycles, Scalable synthesis of cortistatin A and related structures, Terpenoid-alkaloids: Their biosynthetic twist of fate and total synthesis, Practical C-H functionalization of quinones with boronic acids, Oxidative coupling of indoles with 3-oxindoles, Synthesis-guided structure revision of the sarcodonin, sarcoviolin, and hydnellin natural product family, C-H functionalization logic in total synthesis, If C-H bonds could talk: Selective C-H bond oxidation, Total synthesis guided structure elucidation of (+)-psychotetramine, The psychotrimine natural products have antibacterial activity against gram-positive bacteria and act via membrane disruption, Direct C-H arylation of electron-deficient heterocycles with arylboronic acids, Two-phase terpene total synthesis: historical perspective and application to the Taxol problem, Total synthesis of eudesmane terpenes: cyclase phase, Scalable total syntheses of N-linked tryptamine dimers by direct indole-aniline coupling: Psychotrimine and kapakahines B and F, Functional characterization of the cyclomarin/cyclomarazine prenyltransferase cymd directs the biosynthesis of unnatural cyclic peptides, Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines, Sulfhydryl-based dendritic chain reaction, A synthesis of the carbon skeleton of maoecrystal v, Activity-linked labeling of enzymes by self-immolative polymers, Total synthesis of haouamine A: The indeno-tetrahydropyridine core, An improved synthesis of alpha,beta-unsaturated nitrones relevant to the stephacidins and analogs thereof, Scalable total synthesis and biological evaluation of haouamine a and its atropisomer, Total synthesis of eudesmane terpenes by site-selective C-H oxidations, Protecting-group-free synthesis as an opportunity for invention, Enantiospecific total syntheses of kapakahines B and F, A simple method for the direct arylation of indoles, Chemoselectivity: The mother of invention in total synthesis, Direct, chemoselective N-tert-prenylation of indoles by C-H functionalization, Stereodivergent synthesis of 17-alpha and 17-beta-alpharyl steroids: Application and biological evaluation of D-ring cortistatin analogues, Enantiospecific total synthesis of the hapalindoles, fischerindoles, and welwitindolinones via a redox economic approach, Total syntheses of (+/-)-massadine and massadine chloride, Intermolecular enolate heterocoupling: Scope, mechanism, and application, 1,3-diol synthesis via controlled, radical-mediated C-H functionalization, Synthesis of 1,9-dideoxy-pre-axinellamine, Total synthesis of (+/-)-axinellamines A and B, Scope and mechanism of direct indole and pyrrole couplings adjacent to carbonyl compounds: Total synthesis of acremoauxin A and oxazinin 3, Modern synthetic efforts toward biologically active terpenes, Total synthesis of dimeric pyrrole-imidazole alkaloids: Sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton, Total synthesis of marine natural products without using protecting groups, Organic chemistry: A tuxedo for iodine atoms, Massadine chloride: A biosynthetic precursor of massadine and stylissadine, One-step synthesis of 4,5-disubstituted pyrimidines using commercially available and inexpensive reagents, Enantioselective total synthesis of avrainvillamide and the stephacidins, Intermolecular oxidative enolate heterocoupling, Mechanism of the vinylcyclobutane rearrangement of sceptrin to ageliferin and nagelamide E, Oxidative C-C bond formation in heterocyclic chemistry, Short, enantioselective total synthesis of sceptrin and ageliferin by programmed oxaquadricyclane fragmentation, Enantioselective total syntheses of welwitindolinone A and fischerindoles I and G, A remarkable ring contraction en route to the chartelline alkaloids, Direct coupling of pyrroles with carbonyl compounds: Short enantioselective synthesis of (S)-ketorolac, Short, enantioselective total synthesis of stephacidin A, Total synthesis of avrainvillamide (CJ-17,665) and stephacidin B, Direct coupling of indoles with carbonyl compounds: Short, enantioselective, gram-scale synthetic entry into the hapalindole and fischerindole alkaloid families, Sceptrin as a potential biosynthetic precursor to complex pyrrole-imidazole alkaloids: The total synthesis of ageliferin, The first method for protection-deprotection of the indole 2,3-pi bond, Short, enantioselective total synthesis of okaramine n, A short synthetic route to (+)-austamide, (+)-deoxyisoaustamide, and (+)-hydratoaustamide from a common precursor by a novel palladium-mediated indole -> dihydroindoloazocine cyclization, Novel chemistry of alpha-tosyloxy ketones: Applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries, Iodine(V) reagents in organic synthesis. Voica, A. F., Mendoza, A., Gutekunst, W. R., Fraga, J. O., Baran, P. S. Mousseau, G., Clementz, M. A., Bakeman, W. N., Nagarsheth, N., Cameron, M., Shi, J., Baran, P., Fromentin, R., Chomont, N., Valente, S. T. Krenske, E. H., Perry, E. W., Jerome, S. V., Maimone, T. J., Baran, P. S., Houk, K. N. Bruckl, T., Baxter, R. D., Ishihara, Y., Baran, P. S. Dixon, D. D., Lockner, J. W., Zhou, Q. H., Baran, P. S. Lansdell, T. A., Hewlett, N. M., Skoumbourdis, A. P., Fodor, M. D., Seiple, I. Phil S. Baran's 523 research works with 24,181 citations and 5,775 reads, including: Serine-Selective Bioconjugation Racemic and asymmetric synthesis of bicyclo 4.3.1 key building blocks, Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). ‘I’d come in in the morning, and on my desk would be a vial, or an NMR spectrum, of something he’d just made.


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